Loperamide controls noninfectious diarrhea in 81 patients

In order to confirm the efficacy of loperamide for controlling the noniafectious diarrhea, with diphenoxylate Co.(contain 2.5 mg diphenoxylate and 0.025 mg atropine sulfate)as a control,143 patients of noninfectious diarrhea , diagnosed by laboratory stool examinations were studied-81 patients received loperamide while 62 patients diphenoxylate Co.During the acute attack, lopera-mide 4 mg was given per os as an initial dose, followed by 2 mg for 3d. The daily dose was limited to 16 mg as a maximum.For chronic patients, loperamide 2-6 mg /d were given.Dosages for children were adjusted according to their body weight or age. In conclusion, loperamide has the same efficacy as diphenoxylate Co. to control the acute noninfectious diarrhea and the former is even better than the latter for those chro-nic patients to have symptomatic release.In addition, lopera-mide rarely develops adverse reactions.