Changes in Viral Load in Treatment of Severe Hepatitis B with Artificial Liver Plasma Exchange and Its Clinical Significance

Objective To investigate the changes in hepatitis B viral load in patients treated with artificial liver plasma exchange and its clinical significance.Methods A total of 136 patients were randomly divided into observation group(n=76) and control group(n=60).All patients were given comprehensive medical treatment,including bed rest,comprehensive liver protection,promotion of hepatocyte proliferation,and support treatment.The observation group was given additional treatment with artificial liver plasma exchange.The indicators of liver function(TBIL,DBIL,ALB,CHE and PTA),TNF-α,IL-6,LPS,HBV-DNA,symptoms and signs were observed before and after artificial liver support.The survival rate was compared between the two groups.Results In observation group,clinical improvement occurred in 53 patients and death in 23 patients.In control group,clinical improvement occurred in 28 patients and death in 32 patients.The survival rate in observation group was significantly higher than that in control group(69.7% vs 46.6%,P0.05).After treatment with artificial liver plasma exchange,TBIL,TNF-α,IL-6 and LPS markedly decreased(P0.01),PTA and CHE significantly increased(P0.01),and HBV-DNA declined from(7.62±1.68)×107 copies·mL-1 to(4.75±1.35)×104 copies·mL-1(P0.01).Conclusion Artificial liver plasma exchange has a positive impact on severe hepatitis B.It can alleviate hepatitis B viral load and accumulated toxicity and thus increase survival rate among patients with severe hepatitis B.