Effects of Zhitangshu on the Contents of Fructosamine and the Activities of Antioxidases in Serum of the Rats with Type-2-diabetes

Objective To explore the inhibiting effects of Zhitangshu(ZTS) on non-enzyme glycosylation of serum protein and on peroxide of lipid in serum of the rats with type-2-diabetes.Methods The model of rats with type-2-diabeties mellitus was established by using the low dose of streptozotocin(30mg/kg) and high-caloric feeding.The same amount of normal saline and the different does of ZTS were perfused into the stomach of these rats once a day for 9 weeks.The healthy rats were chosen to constitute the control group.The contents of insulin(Ins),glucose(Glu),free fatty acid(FFA) fruetosamine(FMN) and malondialdehyde(MDA) and the activities of superoxide dismutase(SOD),glutathione peroxidase(GSH-PX) and catalase(CAT) in serum were determined and body-weigh index(BMI),insulin resistance index(IRI) and insulin sensitivity index(ISI) were calculated.Results①he BMI,IRI and the contents of FMN,FFA,FIns,FBG and MDA were obviously increased while ISI and the activities of SOD,GSH-PX and CAT markedly decreased in serum of the diabetic rats' model(P0.01,compared with control group).②Both dosage of ZTS could reverse all above indexes(P0.05).③There were remarkable differences of IRI,ISI and FMN between the two dosage ZTS group(P0.05).Conclusion ZTS has remarkable effect of lowering the insulin resistance and inhibiting the non-enzyme glycosylation of serum protein and the lipid-peroxidation in type-2-diabetes rats.