The clinical study of pulmonary surfactant in newborn infants with severe meconium aspiration syndrome

Objective To study the efficacy of pulmonary surfactant (PS) in newborn infants with severe meconium aspiration syndrome (MAS). Methods 83 infants with severe MAS were randomly assigned into two groups. The treatment group (41 cases) were treated with PS 150-240 mg/kg;control group (42 cases) were treated in usually method. Pulmonary oxygenation function, the course of disease and prognosis of each case were observed and monitored. Results At different stages of treatment, oxygenation index (OI) of treatment group decreased more significantly than those of the control group (1 h t=2.521,12 h t=3.423, 24 h t=3.372, 36 h t=3.823, P0.05); The artery to alveolar partial pressure of oxygen ratio (a/APO2) of treatment group increased significantly more than that of control group (1 h t=2.47, P0.05,12 h t=3.724, P0.05,24 h t=3.923, P0.01,36 h t=2.783, P0.05). The parameter of mechanical ventilation in the PS group reduce more quickly. Time spans of mechanical ventilation, hospitalization, pneumothorax and ventilator association pneumonia (VAP) was less than those of control group (t=5.15,9.52,Χ2=8.38,11.7, P0.05). Conclusions PS therapy may result in a rapid improvement in oxygenation, and duration of mechanical ventilation and hospitalization time of newborn infants with severe MAS, reduce pneumothorax and VAP, and improve livability.