Analysis of clinical effect of Adefovir Dipivoxil combined with Thymosin α_1 on chronic hepatitis B

Objective To explore the clinical effect of Adefovir Dipivoxil combined with Thymosin α1 on chronic hepatitis B.Methods Sixty-four patients with chronic hepatitis B were randomly divided into combined treatment group(n=32) and control group(n=32).Patients in control group were only given Adefovir Dipivoxil 10mg/d for 72 weeks,while in combined treatment group,Thymosin was added α1 by the way of subcutaneous injection 1.6 mg twice per week during the first 24 weeks on the basis of control group.The levels of ALT,AST and TBIL were detected before and after treatment.HbeAg/HbeAb seroconversion and HBV-DNA negative conversion rates were observed every 24 weeks.Results No significant differences were found in liver function improvement and HBV-DNA negative conversion rates between two groups.However,the HbeAg/HbeAb seroconversion rates in combined treatment group were significantly higher than those in control group(P0.05).Conclusion The clinical effect of Adefovir Dipivoxil combined with Thymosin α1 are significantly better than Adefovir Dipivoxil only on HbeAg/HbeAb seroconversion in the treatment of chronic hepatitis B.