Effects of ischemic postcondition on reduction of infarction size in swine model of acute myocardial infarction

Objective To investigate the effects of ischemic postcondition on the reduction of infarction size in the swine model of acute myocardial infarction.Methods Ten Diannan small-ear pigs were divided into study group(n=5) and control group(n=5) randomly.A balloon catheter was positioned in the mid-distal left anterior descending (LAD) via right femoral artery under fluoroscopic guidance.The balloon was inflated and occluded LAD for 60 min.In study group,ischemic postconditioning was elicited by eight cycles of 30-s reperfusion,followed by 30-s reocclusion.Serum myocardial enzyme were assessed before ischemia,after 2 h of reperfusion,and after 24 h of reperfusion.After 72 h of reperfusion,infarction size was measured by 2,3,5-triphenyltetrazolium chloride(TTC) staining.Results After 2 h of reperfusion,the values of CK and LDH were higher than that before operation(P0.05),after 24 h of reperfusion,the values of CK and LDH were lower than those in control group(P0.05).In the study group,infarction size was smaller than that in control group(P0.05).Conclusion Ischemic postcondition can reduce infarction size in the swine model of acute myocardial infarction.