Clinical Observation on Qushi Huayu Decoction for 82 Cases of Non-Alcoholic Steatohepatitis with Phlegm-Stasis Accumulation Syndrome

Objective:To evaluate the efficacy of Qushi Huayu Decoction for non-alcoholic steatohepatitis with phlegm-stasis accmulation syndrome.Methods:A randomized controlled trial was conducted on the treatment of non-alcoholic steatohepatitis.Totally 184 patients accorded with the diagnosis standards of non-alcoholic steatohepatitis and phlegm-stasis accumulation syndrome were randomized into Qushi Huayu Decoction group(trial,82 cases) and polyene phosphatidylcholine group(control,82 cases).The course of treatment was 24 weeks.The effect was evaluated by the changes in the TCM syndromes,liver function,lipids and B-ultrasound.Results:The total TCM syndromes improvement effective rates of trial group and control group were 86.11% and 57.53% respectively,and the difference between two groups was statistically significant(χ2=14.596,P0.01).The abdominal distention and flank pain of both groups after treatment were significantly alleviated,which had significant difference between two groups(P0.01).After treatment,the ALT and AST activities in serum of both groups were significantly different from that of pre-treatment(P0.01),and the difference between two groups was statistically significant(P0.01).After treatment,the TG,TC and LDL-C contents in serum of both groups were significantly different from that of pre-treatment(P0.01),and the difference between two groups of TG,TC contents in serum was statistically significant(P0.01).The B ultrasound improvement rates of both group were 87.50% and 67.12% respectively,the difference was statistically significant(χ2=8.562,P0.01).12 weeks of follow-up,the B ultrasound improvement rate of trial group was 81.94%,better than 64.38% of the control group(χ2=5.685,P0.01),and there was no significant difference from that at the end of treatment(χ2=0.858,P0.05).Conclusion:Qushi Huayu Decoction has well efficacy on the treatment of non-alcoholic steatohepatitis with phlegm-stasis accumulation syndrome,and its efficacy is better than that of polyene phosphatidylcholine capsule.