Effects of preoperative parecoxib on interleukin 6 and postoperative analgesia for mastectomy

Objective To investigate the effects of preoperative parecoxib on the levels of interleukin 6(IL-6)and postoperative analgesia for breast surgery.Methods Sixty breast cancer patients undergoing mastectomy were randomly divided into two groups:parecoxib group(group P)and control group(group C),n=30 in each group.All patients received sevoflurane and fentanyl anesthesia.Group P was injected parecoxib 40 mg at 10 minutes before induction of anesthesia,meanwhile group C was injected saline 5ml.All patients received postoperative patient-controlled intravenous analgesia(PCIA)with fentanyl.VAS scores for pain were assessed at postoperative 2,4,8,12,24 hours.The serum levels of IL-6 were measured by ELISA at 10 minutes before induction,4h,8h,and 24 h after surgery.Results Group P had lower VAS scores than group C at 2-12 hafter surgery(P0.05).Compared with 10 minutes before induction,the levels of IL-6 increased significantly at postoperative 4,8,24 hin two groups(P0.01),while group P had lower levels of IL-6than group C(P0.01).Conclusion Preoperative administration of parecoxib has a stronger analgesic effect in breast cancer patients after mastectomy,and decreases the levels of IL-6.