Correlation analysis of meningioma recurrence after total resection and its MRI characteristics

Objective To study the MRI features of meningiomas with high recurrence and the relationship among MRI characteristics, pathological grades and proliferating cell nuclear antigen label index (PCNA LI) of meningiomas, to instruct the clinical treatment and prognosis prediction.Methods The clinical, MRI and pathological data of 77 patients with meningioma after total removal were studied respectively. All the patients were divided into the recurrence group and the non-recurrence group according to the follow-up results, and comparing the MRI features between the two groups. By pathological investigation and PCNA immunohistochemistry, the relationship among MRI features, tumor recurrence, pathological grades and PCNA LI were analyzed.Results ①The meningiomas with lobular or mushroom shape, without clear interface with normal brain, and within 1 cm from sinus were prone to recur, and there was no significant correlation between dural tail sign and tumor recurrent rate; ②The meningiomas with higher PCNA LI were more likely to recur than the counterpart; ③The recurrent rate of endotheliomatous meningiomas was higher than those of other subtype groups, and the recurrence was in a pathological grade dependant manner.Conclusion The meningiomas with lobular or mushroom shape, without clear margin and near sinus are prone to recur, the comprehensive approaches should be adopted to postpone or devoid recurrence.