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2012•The Chinese Journal of DermatovenereologyRequires access

Comparison of Enzyme-linked Immunosorbent Assay Test with Immunoblot Assay in the Diagnosis of Pemphigus

Meng Pan

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Abstract

Objective To compare the methods of ELISA and IBT in detecting the specific antibodies in the patients with pemphigus. Methods Twenty-three pemphigus patients(PV-13,PF-10) and 10 controls were enrolled in the study. ELISA and IBT were performed for detecting anti-Dsg 1 and Dsg 3 antibodies. Results The rate of positivity of the two methods were both 91.30%. There were no significant statistic differences (P=0.400 and 1.000 respectively). Conclusion Both ELISA and IBT are important in the diagnosis of pemphigus .ELISA is more convenient and helpful.

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What this paper is about

Objective To compare the methods of ELISA and IBT in detecting the specific antibodies in the patients with pemphigus. Methods Twenty-three pemphigus patients(PV-13,PF-10) and 10 controls were enrolled in the study. ELISA and IBT were performed for detecting anti-Dsg 1 and Dsg 3 antibodies. Results The rate of positivity of the two methods were both 91.30%. There were no significant statistic differences (P=0.400 and 1.000 respectively). Conclusion Both ELISA and IBT are important in the diagnosis of pemphigus .ELISA is more convenient and helpful.

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Available abstract

Objective To compare the methods of ELISA and IBT in detecting the specific antibodies in the patients with pemphigus. Methods Twenty-three pemphigus patients(PV-13,PF-10) and 10 controls were enrolled in the study. ELISA and IBT were performed for detecting anti-Dsg 1 and Dsg 3 antibodies. Results The rate of positivity of the two methods were both 91.30%. There were no significant statistic differences (P=0.400 and 1.000 respectively). Conclusion Both ELISA and IBT are important in the diagnosis of pemphigus .ELISA is more convenient and helpful.

Key concepts: Pemphigus, Medicine, Antibody, Pemphigus vulgaris, Dermatology, Immunology

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