Distributions and significances of HPV-16 subtype and HPV-58 subtype of persist infection state in cervical intraepithelial neoplasia and cervical cancer

Objective:To research the distributions and significances of high risk human papillomavirus(HPV)-16 subtype and HPV-58 subtype of persist infection state in the patients with cervical lesions.Methods:Molecular diversion hybridization technique was used to detect the distributions of HPV-16 subtype and HPV-58 subtype of persist infection state in 10 477 cases with chronic cervicitis,3 672 cases with cervical intraepithelial neoplasia(CIN),and 1 108 cases with cervical cancer.Results:The positive rate of HPV-16 subtype of persistent infection in chronic cervicitis group was 0.41%(95%CI: 0.29%-0.53%),the positive rate of HPV-16 subtype of persistent infection in CIN I group was 3.00%(95%CI: 2.26%-3.74%),the positive rate of HPV-16 of persistent infection in CINⅡ/Ⅲ group was 15.40%(95%CI: 13.63%-17.17%),the infection rate of HPV-16 subtype showed a gradual increasing trend,there was statistically significant difference among the three groups(P0.05).The positive rate of HPV-58 subtype of persistent infection in chronic cervicitis group was 0.56%(95%CI: 0.42%-0.70%),the positive rate of HPV-58 subtype of persistent infection in CIN I group was 2.66%(95%CI: 2.36%-3.46%),the positive rate of HPV-58 subtype of persistent infection in CINⅡ/Ⅲ group was 6.92%(95%CI: 5.68%-8.16%),the infection rate of HPV-58 subtype showed a gradual increasing trend,there was statistically significant difference among the three groups(P0.01).There was no significant correlation between persistent infection of HPV-16 subtype and various clinicopathological parameters(P0.05).The onset age of cervical cancer in the patients with persistent infection of HPV-58 subtype was statistically significantly older than those in the patients with opportunistic infection of HPV-58 subtype or without HPV-58 subtype infection(P0.05).Conclusion:Persistent infections of HPV-16 subtype and HPV-58 subtype play important roles in the occurrence and development of cervical precancerous lesion,HPV-16 subtype and HPV-58 subtype are promised to be risk evaluation indexes to predict the progress of CIN.Regular detection of high risk HPV subtypes has important directive significance for prediction,prevention,and treatment of cervical lesions.