Clinical Effect and Safety of Different Doses of Atorvastatin in Elderly Patients with Hyperlipidemia Combined with Coronary Heart Disease

Objective To evaluate the clinical efficacy and safety of different doses of atorvastatin on elderly patients with coronary heart disease combined with hyperlipidemia.Methods A total of 120 elderly patients with coronary heart disease and hyperlipidemia were in Shenzhen Futian Second People' s Hospital from May 2011 to Dec.2013 were included in the study,and they were randomly divided into low dose group and high dose group by coin toss method,60 cases in each group.Low dose group were given atorvastatin20 mg daily,high dosage group was given 40 mg daily,both taken 30 minutes after dinner,8 consecutive weeks as one course.The clinical efficacy,the incidence of cardiovascular events during treatment,and blood lipid changes etc of the two groups were compared.Results The total effective rate of the high dose group was 86.7%,of the low dose group was 70.0%,the difference was statistically significant(P 0.01).The levels of total cholesterol(TC),triglyceride(TG) and low density lipoprotein cholesterol(LDL-C) of both groups after 8 weeks of treatment were significantly decreased than before treatment,the differences were statistically significant(P 0.01),high density lipoprotein cholesterol(HDL-C) levels was significantly increased after the treatment(P 0.01).After 8 weeks of treatment,levels of TC,TG and HDL-C in th high dose group were significantly higher than the low dose group,while LDL-C level was significantly lower than the low dose group,the differences were statistically significant(P 0.01).During the treatment,the cardiovascular events rate in the high dose group were significantly lower than the low dose group,the difference was statistically significant(P 0.05).There were no obvious adverse reaction observed in both group,and all patients completed the treatment.Conclusion High dose atorvastatin in the treatment of elderly patients with coronary heart disease and hyperlipidemia has obvious effect,with high safety,thus has a high clinical value.