Relationship between Lipoprotein(a)and Homocysteine with Carotid Artery Atherosclerosis in Middle and Elderly Hypertensive Patients

Objective:To analysis relationship between the serum lipoprotein a [Lp(a)]and homocysteine(Hcy)levels with the degree of carotid atherosclerosis.Method:120cases with hypertension patients in middle-aged(45-65,57.4±7.5years)were choosed and divided into three groups,including the intima-media thickness(IMT)normal group(n=58),the IMT thickening group(n=39),and the atheroma group(n=23),which according to the degree of carotid artery atherosclerosis under carotid ultrasound examination.To parallel detecte Lp(a)and Hcy for analysis of the statistical differences between groups.Results:The levels of serum Lp(a),Hcy of the IMT thickening group and the atheroma group were higher than IMT normal group(P0.05,P0.001).The levels of serum Lp(a)、Hcy of the atheroma group were higherthan IMTthickening group.The difference was statistically significant(P0.05).Logistic stepwise regression analysis found that the LP(a),Hcy were positively correlated carotid artery I MT(P0.05).Conclusion:High level of serum Lp(a),Hcy in middle-aged patients with hypertansion might promote atherosclerosis.