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[Vitamin K epoxide reductase complex 1 gene polymorphism and warfarin dose requirement in Chinese patients].

Nianxin Jiang, Jie Song, Biao Xu

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Abstract

OBJECTIVE: To investigate the possible relationship between vitamin K epoxide reductase complex 1 (VKORC1) gene polymorphism and warfarin dose requirements in Chinese patients. METHOD: Genotyping for the C1173T polymorphism in the VKORC1 gene was performed using a restriction enzyme digestion of PCR-amplified DNA in 102 Chinese patients treated with warfarin. RESULTS: TT genotype was found in 83 patients (81.4%), CT genotype in 16 patients (15.7%) and CC genotype in 3 patients (2.9%). To achieve similar target INR range (1.5 - 2.5), the warfarin dose requirement was significantly lower in patients with TT genotype than that in patients with CT/CC genotypes (P < 0.01). CONCLUSION: C1173T polymorphism in the VKORC1 gene might be one important determinant for warfarin dose requirement in Chinese patients.

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What this paper is about

OBJECTIVE: To investigate the possible relationship between vitamin K epoxide reductase complex 1 (VKORC1) gene polymorphism and warfarin dose requirements in Chinese patients. METHOD: Genotyping for the C1173T polymorphism in the VKORC1 gene was performed using a restriction enzyme digestion of PCR-amplified DNA in 102 Chinese patients treated with warfarin. RESULTS: TT genotype was found in 83 patients (81.4%), CT genotype in 16 patients (15.7%) and CC genotype in 3 patients (2.9%). To achieve similar target INR range (1.5 - 2.5), the warfarin dose requirement was significantly lower in patients with TT genotype than that in patients with CT/CC genotypes (P < 0.01). CONCLUSION: C1173T polymorphism in the VKORC1 gene might be one important determinant for warfarin dose requirement in Chinese patients.

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Available abstract

OBJECTIVE: To investigate the possible relationship between vitamin K epoxide reductase complex 1 (VKORC1) gene polymorphism and warfarin dose requirements in Chinese patients. METHOD: Genotyping for the C1173T polymorphism in the VKORC1 gene was performed using a restriction enzyme digestion of PCR-amplified DNA in 102 Chinese patients treated with warfarin. RESULTS: TT genotype was found in 83 patients (81.4%), CT genotype in 16 patients (15.7%) and CC genotype in 3 patients (2.9%). To achieve similar target INR range (1.5 - 2.5), the warfarin dose requirement was significantly lower in patients with TT genotype than that in patients with CT/CC genotypes (P < 0.01). CONCLUSION: C1173T polymorphism in the VKORC1 gene might be one important determinant for warfarin dose requirement in Chinese patients.

Key concepts: VKORC1, Vitamin K epoxide reductase, Warfarin, Genotype, Genotyping, Medicine, Polymorphism (computer science), Gene polymorphism

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[Vitamin K epoxide reductase complex 1 gene polymorphism and warfarin dose requirement in Chinese patients]. — Research Paper | ScholarLens