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2007•Chinese Journal of Clinical HepatologyRequires access

The diagnosis value of hyaluronic acid, typeIIIprocollagen, type collagen and proline dipeptidase in liver fibrosis

Kun Cui

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Abstract

To determine the relationship between hyaluronic acid(HA),typeⅢ procollagen(PCⅢ),type-Ⅳ collagen(CⅣ) or proline dipeptidase(PLD) and degree of liver fibrosis.HA,PCⅢ,CⅣ and PLD in the serum from 225 pa-tients with all type of liver disease were measured by ELISA and biochemistry colorimetry and analyzed their relationshipwith the pathological inflammation-grade and fibrosis-stage of liver biopsy tissues.There were significant correlation(P0.05) between the four indexes and the degree of inflammation,necrosis and fibrosis.The serological indexes are in ac-cordance with the pathological degree of live tissues.It could reflect both the severe degree of hepatofibrosis and the statusof hepatocellular necrosis by co-measuring HA、PCⅢ or CⅣ and PLD in the serum,that provides reference for clinicaldiagnosis and treatment.

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What this paper is about

To determine the relationship between hyaluronic acid(HA),typeⅢ procollagen(PCⅢ),type-Ⅳ collagen(CⅣ) or proline dipeptidase(PLD) and degree of liver fibrosis.HA,PCⅢ,CⅣ and PLD in the serum from 225 pa-tients with all type of liver disease were measured by ELISA and biochemistry colorimetry and analyzed their relationshipwith the pathological inflammation-grade and fibrosis-stage of liver biopsy tissues.There were significant correlation(P0.05) between the four indexes and the degree of inflammation,necrosis and fibrosis.The serological indexes are in ac-cordance with the pathological degree of live tissues.It could reflect both the severe degree of hepatofibrosis and the statusof hepatocellular necrosis by co-measuring HA、PCⅢ or CⅣ and PLD in the serum,that provides reference for clinicaldiagnosis and treatment.

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Available abstract

To determine the relationship between hyaluronic acid(HA),typeⅢ procollagen(PCⅢ),type-Ⅳ collagen(CⅣ) or proline dipeptidase(PLD) and degree of liver fibrosis.HA,PCⅢ,CⅣ and PLD in the serum from 225 pa-tients with all type of liver disease were measured by ELISA and biochemistry colorimetry and analyzed their relationshipwith the pathological inflammation-grade and fibrosis-stage of liver biopsy tissues.There were significant correlation(P0.05) between the four indexes and the degree of inflammation,necrosis and fibrosis.The serological indexes are in ac-cordance with the pathological degree of live tissues.It could reflect both the severe degree of hepatofibrosis and the statusof hepatocellular necrosis by co-measuring HA、PCⅢ or CⅣ and PLD in the serum,that provides reference for clinicaldiagnosis and treatment.

Key concepts: Hyaluronic acid, Fibrosis, Procollagen peptidase, Pathological, Pathology, Liver biopsy, Hydroxyproline, Necrosis

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The diagnosis value of hyaluronic acid, typeIIIprocollagen, type collagen and proline dipeptidase in liver fibrosis — Research Paper | ScholarLens