Effect of N-terminal pro-brain natriuretic peptide on prognosis of patients with acute STEMI after primary PCI

Objective To assess the long-term effect of N-terminal pro-brain natriuretic peptide (NT-proBNP) on prognosis of patients with ST elevation myocardial infarction(STEMI) after primary PCI.Methods One hundred and twenty-five STEMI patients with chest pain who underwent PCI within 12 h after admission from December 2008 to June 2010 were divided into cardiac event group(n = 22) and non cardiac event group(n= 103) according to the occurrence of cardiac events during follow-up.NT-proBNP level was measured within 12 h after admission.The patients were followed up for 1 year,during which the incidence of cardiac events was observed.Results The NT-proBNP level was significantly higher in cardiac event group than in non cardiac event group(P0.05).The area under ROC curves for NT-proBNP was 0.778.Kaplan-Meier analysis showed that the 1-year survival rate was significantly higher in free cardiac event patients with their NT-proBNP level729 pmol/L than in those with their NT-proBNP level729 pmol/L(P0.01).Cox regression analysis showed that the peak NT-proBNP,LVEF and cTnI values were the independent predicting factors for the long-term outcomes of cardiovascular events in acute STEMI patients after primary PCI.Conclusion NT-proBNP can predict the long-term outcomes in acute STEMI patients after primary PCI.