Application of Plasma Aminophylline Concentration Monitoring in Tumor Patients

Objective: To investigate the effect of various factors on plasma concentration of aminophylline in tumor patients and ensure the safety and utility of its clinical medication. Methods: Therapeutic window of aminophylline was set as 5~20 μg·mL-1. Plasma concentration of aminophylline was determined by high performance liquid chromatography(HPLC) and the results were analyzed statistically. Results: Among the 68 sampled cases, 57.4% of the cases were within the effective plasma concentration range of 5 to 20 μg·mL-1, of which 28 cases showed therapeutic efficacy, accounting for 71.8% of the 39cases; The incidence of toxic effect was 7.7%(3 cases). For the 19 cases with plasma concentration under 5μg·mL-1, the effective rate was 31.6%(6 cases). Among the 10 cases with plasma concentration over 20 μg·mL-1, 3 cases showed therapeutic efficacy and a variety of toxic manifestations were observed in the other7 cases. Plasma concentration of aminophylline was increased when it was used in combination with cimetidine or ciprofloxacin, and was decreased with domperidone, nifedipine or terbutaline. Conclusion: Plasma concentration of aminophylline in tumor patients was affected by various factors. It's necessary to monitor its plasma concentration timely, especially when it is used in combination with other drugs, which is of great significance to reduce its toxic effect and ensure its therapeutic efficacy.