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2013•Zhongguo xin yao zazhiRequires access

Preparation and in vitro release of 4-aminopyridine sustained-release pellets

Bo Hu

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Abstract

Objective:To prepare 4-aminopyridine sustained-release pellets.Methods:Extrusion-spheronization technique was introduced to prepare 4-aminopy-ridine uncoated pellets and Eudragit dispersions were used as coating materials.The in vitro dissolution of the pellets was determined.Results:The prepared 4-aminop-yridine sustained-release pellets had a high roundness and the particle size was homogeneous.The release percentage was 40.6% in the first two hours and almost complete in the later ten hours.Conclusion:The release of 4-aminopyridine from sustained-release pellets is slow and steady;and the preparation technology is easy to operate.

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What this paper is about

Objective:To prepare 4-aminopyridine sustained-release pellets.Methods:Extrusion-spheronization technique was introduced to prepare 4-aminopy-ridine uncoated pellets and Eudragit dispersions were used as coating materials.The in vitro dissolution of the pellets was determined.Results:The prepared 4-aminop-yridine sustained-release pellets had a high roundness and the particle size was homogeneous.The release percentage was 40.6% in the first two hours and almost complete in the later ten hours.Conclusion:The release of 4-aminopyridine from sustained-release pellets is slow and steady;and the preparation technology is easy to operate.

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Available abstract

Objective:To prepare 4-aminopyridine sustained-release pellets.Methods:Extrusion-spheronization technique was introduced to prepare 4-aminopy-ridine uncoated pellets and Eudragit dispersions were used as coating materials.The in vitro dissolution of the pellets was determined.Results:The prepared 4-aminop-yridine sustained-release pellets had a high roundness and the particle size was homogeneous.The release percentage was 40.6% in the first two hours and almost complete in the later ten hours.Conclusion:The release of 4-aminopyridine from sustained-release pellets is slow and steady;and the preparation technology is easy to operate.

Key concepts: Pellets, 4-Aminopyridine, Materials science, Dissolution, Extrusion, Particle size, Homogeneous, Pellet

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