Clinical Observation of Irbesartan and Hydrochlorothiazide Irbesartan on the Treatment of Essential Hypertension

Objective To study the effect and safety of the light-moderate hypertension treatment using irbesartan and hydrochlorothiazide irbesartan. Methods Selected light-moderate hypertension patients were randomly split into 2 groups, one group was treated with hydrochlorothiazide irbesartan while irbesartan used for the other group for comparison. Total treatment period is 8 months,based on 4 months observation to decide either keep the current level or double it. Results Total treatment efficiency using hydrochlorothiazide irbesartan is 97. 5% ,while using irbesartan the efficiency is 82. 5% ,substantial difference observed (P0. 01) ,the occurrence of negative reaction for both groups is 5% . Conclusion Using hydrochlorothiazide irbesartan is effective for light-moderate hypertension,negative effect occurrence is low.