Toxicological Studies on Shengxue Capsules

Objective To observe the acute and chronic toxical reactions of Shengxue Capsules on mice and rats to suggest the reference dosage for humans.Methods Shengxue Capsules were ig administrated to mice and rats twice a day,24 and 16 g/kg,respectively.The mortality rate and drug toxicity were observed and recorded.During long-term toxicological studies,rats were given capsules by intragastric administration at the dosage of 0.5,2.5,5.0 g/kg,respectively,twice a day for 26 weeks.Hematology,blood biochemistry,measure weights and weight indexes,and pathological changes in major organs were examined at 13th week,26th week and 4 weeks after drug withdrawal.Results The maximum ig administration dosage was greater than 24 g/kg in mice and 16 g/kg in rats,240 and 160 times the clinical dosage in humans.Hematology,blood biochemistry,weights and weight indexex of rats were proved to be in the normal range and no pathologic changes in major organs were found.Conclusion Shengxue Capsules are safe at the prescribed dose.