2010•Acta Academiae Medicinae XuzhouRequires access

Eeffect of N-acetylcysteine on brain ischemia/reperfusion-induced gastric mucosa injury in rats

Chunmei Ji

Abstract

Objective To investigate the effect of antioxidant N-acetylcysteine(NAC) on brain ischemia /reperfusion-induced stress gastric mucosa injury in rats.Methods Rat models of brain ischemia/reperfusion were established by the four vessel occlusion method.Following brain ischemia,NAC(150 mg/kg) was injected into the femoral vein.The rats were finally sacrificed to investigate gastric mucosal damage index(GMDI) and determine the content of malondialdehyde(MDA) and the activity of superoxide dismutase(SOD) in gastric mucosa.The apoptosis of gastric mucosal cells was detected by TUNEL.Results Injection of NAC into the femoral vein could decrease gastric mucosal damage index in stress gastric injury,reduce the content of MDA and increase the activity of SOD in the gastric mucosa,and inhibit gastric mucosal cellular apoptosis following brain ischemia/reperfusion.Conclusion NAC could protect against brain ischemia/reperfusion-induced stress gastric injury by the inhibition of oxidative stress and redction of cell apoptosis in gastric mucosa.

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Key concepts: Gastric mucosa, Malondialdehyde, Ischemia, TUNEL assay, Superoxide dismutase, Acetylcysteine, Medicine, Oxidative stress