Influence of percutaneous coronary intervention on brain natriuretic peptide and ventricular remodeling in patients with acute ST elevation myocardial infarction

Objective:To explore influence of percutaneous coronary intervention(PCI)on brain natriuretic peptide(BNP)level and ventricular remodeling in patients with acute ST elevation myocardial infarction(STEMI).Methods:According to their therapeutic methods,a total of 151patients diagnosed as STEMI were divided into group A(n=52,received emergency PCI treatment),group B(n=49,received selective PCI treatment)and group C(n=50,received standard medication).BNP level and left ventricular remodeling were compared among three groups before treatment and after treatment.Results:There was no significant difference in BNP level among three groups before treatment(F=0.01,P0.05),BNP level significantly decreased among three groups after treatment,compared with group B and C,there was significant decrease in BNP level[(466.2±113.5)ng/L vs.(601.4±126.7)ng/L vs.(242.7±101.3)ng/L]in group A(P0.01all).There were no significant difference in left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),left ventricular ejection fraction(LVEF)and left ventricular fractional shortening(LVFS)among three groups before treatment(P0.05all);after treatment,there were significant increase in above ventricular indexes in three groups(P0.05all),compared with group C,there were significant increase in LVFS[(22.6±6.9)%vs.(28.9±7.6)%vs.(27.5±7.3)%]in group A and B,compared with group B and C,there was significant increase in LVEF[(53.1±6.5)%vs.(50.9±5.7)%vs.(57.9±6.2)%]in group A(P0.01all).Conclusion:PCI could effectively improve ventricular remodeling and decrease BNP level in STEMI patients,and emergency PCI shows more significant therapeutic effects than selective PCI.