Developments in Non-Viral Vector Researches in Gene Therapy

One of the major challenges for successful cancer gene therapy is the development of safe and effective gene delivery vectors.In gene delivery vectors,non-viral vectors have shown a promising perspective because of their low-toxic,non-immunogenic,non-oncogenic and easy-to-produce properties.This article reviews the recent studies from the characters,mechanisms of transfection and factors of affecting transfection effects of non-viral vectors such as naked DNA,liposome and lipoplexes,polyplex including polyethylenimine and chitosan,and molecular conjugates used in cancer gene therapy.