Sclerosing angiomatoid nodular transformation of spleen: a clinicopathologic study of 6 cases

Objective To study the clinicopathologic features,diagnosis and differential diagnosis of sclerosing angiomatoid nodular transformation(SANT) of the spleen.Methods Six cases of sclerosing angiomatoid nodular transformation of spleen were retrieved.The clinical data,pathologic characteristics and immunophenotype were studied.Results Sclerosing angiomatiod nodular transformation was characterized by multiple angiomatiod nodules in a fibrosclerotic stroma.The nodules were composed of slit-like,irregular-shaped slightly dilated vascular spaces lined plump endothelial cells and interspersed by a population of spindle or ovoid cells.The internodular stroma was scattered with lymphocytes,plasma cells and histocytes.Immunohistochemistry revealed 3 distinct types of vessels in the angiomatoid nodules: CD34 + / CD31 + / CD8-,CD34-/ CD31 + / CD8 + and CD34-/ CD31 + / CD8-.The spindle cells of the nodules showed staining for CD31,SMA and CD68.CD68 and SMA were positive in the spindle cells of the internodular area.Conclusion Sclerosing angiomatoid nodular transformation of spleen is a rarely benign and characteristic lesion,which should particularly be distinguished from borderline or malignant tumors of the spleen.