Pathological analysis of sclerosing anagiomatoid nodular transformation of spleen

Objective To review the clinicopathological features,diagnosis and differential diagnosis of sclerosing angiomatoid nodular transformation(SANT)of spleen.Methods The clinical data,pathological findings,immunophenotypes and postoperative follow-up of 4 cases of SANT were investigated.Results There were no specific clinical manifestations in 4 cases of SANT,in which 3 cases were found in health check-up.Two were male and two female.Grossly,on the cut surface the masses were gray-white and un-encapsulated nodular measuring 3~5.9 cm in size.Microscopically,SANT was characterized by micronodular lesions consisting of vascular spaces lined by plump endothelial cells with interspersed spindle cells.Immunohistochemical results showed that the endothelial cells of vessels in angiomatoid nodules had various phenotypes: CD34+/CD31+/CD8-in endothelial cells of capillaries,CD34-/CD31+/CD8+ in lining cells of the sinusoids and CD34-/CD31+/CD8-in endothelial cells of small veins.All patients were alive.Conclusions SANT is a benign lesion specially arising in spleen with a characteristic pathological appearance.The diagnosis relies on the pathological and immunohistochemical findings.The disease can be cured by splenectomy with a favorable prognosis.