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Correlation of hormone receptors expression and response to neoadjuvant chemotherapy in breast cancer

Shu Wang

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Abstract

Objective To study the correlation between expression of estrogen receptor(ER),expression of progesterone receptor (PR) and the response to neoadjuvant chemotherapy in breast cancer. Methods Forty-six patients with breast cancer were treated with neoadjuvant chemotherapy. ER and PR were examined immunohistochemically before chemotherapy and the response was evaluated after it. Results Seventeen patients achieved clinic complete release (cCR)and nine pathology complete release (pCR), 21 partial release (PR) and 8 no change (NC). The overall response rate was 82.6% and the pCR rate was 19.57%. Difference in response was observed between the patients with ER and PR absent and those with ER and/or PR positive tumors (90.9% vs. 75%). Pathology CR rates were also different in the two groups (27.3% vs. 12.5%), but without statistical significance. Conclusion Breast cancer with ER and PR absent may be more sensitive to neoadjuvant chemotherapy.

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Objective To study the correlation between expression of estrogen receptor(ER),expression of progesterone receptor (PR) and the response to neoadjuvant chemotherapy in breast cancer. Methods Forty-six patients with breast cancer were treated with neoadjuvant chemotherapy. ER and PR were examined immunohistochemically before chemotherapy and the response was evaluated after it. Results Seventeen patients achieved clinic complete release (cCR)and nine pathology complete release (pCR), 21 partial release (PR) and 8 no change (NC). The overall response rate was 82.6% and the pCR rate was 19.57%. Difference in response was observed between the patients with ER and PR absent and those with ER and/or PR positive tumors (90.9% vs. 75%). Pathology CR rates were also different in the two groups (27.3% vs. 12.5%), but without statistical significance. Conclusion Breast cancer with ER and PR absent may be more sensitive to neoadjuvant chemotherapy.

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Available abstract

Objective To study the correlation between expression of estrogen receptor(ER),expression of progesterone receptor (PR) and the response to neoadjuvant chemotherapy in breast cancer. Methods Forty-six patients with breast cancer were treated with neoadjuvant chemotherapy. ER and PR were examined immunohistochemically before chemotherapy and the response was evaluated after it. Results Seventeen patients achieved clinic complete release (cCR)and nine pathology complete release (pCR), 21 partial release (PR) and 8 no change (NC). The overall response rate was 82.6% and the pCR rate was 19.57%. Difference in response was observed between the patients with ER and PR absent and those with ER and/or PR positive tumors (90.9% vs. 75%). Pathology CR rates were also different in the two groups (27.3% vs. 12.5%), but without statistical significance. Conclusion Breast cancer with ER and PR absent may be more sensitive to neoadjuvant chemotherapy.

Key concepts: Breast cancer, Estrogen receptor, Chemotherapy, Medicine, Oncology, Internal medicine, Complete response, Neoadjuvant therapy

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