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Expression of Endostatin in Placenta with Intrahepatic Cholestasis of Pregnancy

Qian Xu

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Abstract

Objective:To investigate the expression of endostatin(ES) in placenta from patients with intrahepatic cholestasis of pregnancy(ICP).Methods:The expression of ES in 25 placentas from normal pregnancy(control group) and 25 placentas from ICP(ICP group) was detected by immunohistochemistry.Results:The distribution of ES in placenta was found similar for both control and ICP groups in villous trophoblast,blood vessels and stroma.Rating ES expression as light,moderate and strong,the incidences were 28%,36% and 36% in ICP group and 32%,56%,and 12% in control group,respectively.The level of ES was significantly higher in ICP group than that in control group(P0..01).Conclusion:The increase of ES in placenta from ICP may be related to inadequate blood vessel formation and abnormal invasion of trophoblast and may play a role in the cause of ICP.

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Objective:To investigate the expression of endostatin(ES) in placenta from patients with intrahepatic cholestasis of pregnancy(ICP).Methods:The expression of ES in 25 placentas from normal pregnancy(control group) and 25 placentas from ICP(ICP group) was detected by immunohistochemistry.Results:The distribution of ES in placenta was found similar for both control and ICP groups in villous trophoblast,blood vessels and stroma.Rating ES expression as light,moderate and strong,the incidences were 28%,36% and 36% in ICP group and 32%,56%,and 12% in control group,respectively.The level of ES was significantly higher in ICP group than that in control group(P0..01).Conclusion:The increase of ES in placenta from ICP may be related to inadequate blood vessel formation and abnormal invasion of trophoblast and may play a role in the cause of ICP.

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Available abstract

Objective:To investigate the expression of endostatin(ES) in placenta from patients with intrahepatic cholestasis of pregnancy(ICP).Methods:The expression of ES in 25 placentas from normal pregnancy(control group) and 25 placentas from ICP(ICP group) was detected by immunohistochemistry.Results:The distribution of ES in placenta was found similar for both control and ICP groups in villous trophoblast,blood vessels and stroma.Rating ES expression as light,moderate and strong,the incidences were 28%,36% and 36% in ICP group and 32%,56%,and 12% in control group,respectively.The level of ES was significantly higher in ICP group than that in control group(P0..01).Conclusion:The increase of ES in placenta from ICP may be related to inadequate blood vessel formation and abnormal invasion of trophoblast and may play a role in the cause of ICP.

Key concepts: Cholestasis of pregnancy, Placenta, Trophoblast, Immunohistochemistry, Endostatin, Andrology, Stroma, Pregnancy

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