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2012•Ningxia Medical JournalRequires access

Expression of PDCD5 in degenerative human lumbar intervertebral discs

Cai Li-jun

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Abstract

Objective To investigate the expression of PDCD5 in degenerative human lumbar intervertebral discs,and to research the relationship between PDCD5 and the human lumbar intervertebral discs degeneration.Methods PDCD5 were measured by immunohistochemistry staining in 26 protruded lumbar intervertebral discs tissues(degeneration group) and 10 non-degenerate lumbar discs tissues(control group).Results The expression of PDCD5 in nucleus pulposus tissues in degeneration group was significantly higher than that in control group(P0.05).Conclusion The expression of PDCD5 is positive in two groups,the expression positive rate of PDCD5 in degeneration group is significantly higher than that in control group.The finding suggested that PDCD5 is involved in pathomechanism of lumbar intervertebral disc degeneration.

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What this paper is about

Objective To investigate the expression of PDCD5 in degenerative human lumbar intervertebral discs,and to research the relationship between PDCD5 and the human lumbar intervertebral discs degeneration.Methods PDCD5 were measured by immunohistochemistry staining in 26 protruded lumbar intervertebral discs tissues(degeneration group) and 10 non-degenerate lumbar discs tissues(control group).Results The expression of PDCD5 in nucleus pulposus tissues in degeneration group was significantly higher than that in control group(P0.05).Conclusion The expression of PDCD5 is positive in two groups,the expression positive rate of PDCD5 in degeneration group is significantly higher than that in control group.The finding suggested that PDCD5 is involved in pathomechanism of lumbar intervertebral disc degeneration.

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Available abstract

Objective To investigate the expression of PDCD5 in degenerative human lumbar intervertebral discs,and to research the relationship between PDCD5 and the human lumbar intervertebral discs degeneration.Methods PDCD5 were measured by immunohistochemistry staining in 26 protruded lumbar intervertebral discs tissues(degeneration group) and 10 non-degenerate lumbar discs tissues(control group).Results The expression of PDCD5 in nucleus pulposus tissues in degeneration group was significantly higher than that in control group(P0.05).Conclusion The expression of PDCD5 is positive in two groups,the expression positive rate of PDCD5 in degeneration group is significantly higher than that in control group.The finding suggested that PDCD5 is involved in pathomechanism of lumbar intervertebral disc degeneration.

Key concepts: Degeneration (medical), Lumbar, Medicine, Immunohistochemistry, Intervertebral disc, Pathology, Anatomy

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