The Effects of Hyperlipidemia on Early Changes of Arteries in Hypertensive Patients

Aim To examine the changes of brachial-ankle pulse wave velocity(baPWV) and ankle-brachial index(ABI) in hypertensive patients with hyperlipidemia and estimate the related factors of baPWV in hypertensive patients.Methods 400 hypertensive patients and 400 hypertensive patients with hyperlipidemia were selected from the health center of the third Xiangya hospital,blood pressure(BP) and age were adjusted between two groups.ABI,baPWV,triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDLC),low-density lipoprotein cholesterol(LDLC) and fasting blood sugar(FBS) were detected by VP1000 or blood tests.The baPWV value between the two groups was examined by T test.There were four sub-groups about hyperlipidemia,ANOVA analysis was used to estimate the differences between these sub-groups.The relationship between blood pressure,age,lipids and baPWV was analyzed by correlation analysis,further multiple linear regression analysis was used to explore the effect of related factors on baPWV and a model was constructed. Results The baPWV value in hypertensive patients with hyperlipidemia group(1674.0±13.0 cm/s) was significantly higher than that in hypertensive patients group(1594.0±11.2 cm/s)(P0.001).There was no significant difference of ABI value between two groups(P=0.897).In hypertensive patients,hyperglyceridemia increased the baPWV value,as well as hypercholesterolaemia.Correlation analysis demonstrated that TC,LDLC,TC/HDLC were relevant to baPWV value(P0.05). Conclusions Lipids are relevant to baPWV,hyperlipidemia accelerated arteriosclerosis in the patients with hypertension,hyperglyceridemia is also related to the stiffness of arteries as hypercholesterolaemia.