Reverse effects of salidroside on expression of c-myc in SMMC-7721 cell line in vitro

Objective:To study the reverse effects of salidroside on expression of c-myc in SMMC-7721 cell line.Methods: The cultured SMMC-7721 cell lines were pre-treated by different dosages of salidroside in vitro and then the level of expression of c-myc was determined with immunohistochemistry.Results: All of three dosage(0.5 mg/ml,1.0 mg/ml and 1.5 mg/ml) of salidroside could inhibited the expression of c-myc in SMMC-7721 cell lines and inhibited rates were 8.8%,21.6% and 39.8%,respectively.There was a positive dosage-dependent relationship.Conclusion: Salidroside is of reverse effects on expression of c-cym in SMMC-7721 cell lines,which indicates that it may induce differentiation of hepatoma carcinoma cell in vitro.