Relationship of hypoxia inducible factor 1α and vascular endothelial growth factor expression with angiogenesis in gastric carcinoma

Objective To investigate the expression of hypoxia inducible factor 1α(HIF-1α),vascular endothelial growth factor(VEGF) and micro vessel density(MVD) in gastric carcinoma and to explore their correlation with clinical pathological features such as cancer invasion and metastasis.Methods Forty-eight samples of gastric carcinoma tissues were examined for the expression of HIF-1α,VEGF and CD34 by immunohistochemical method.Results The positive expression rates of HIF-1α and VEGF were 66.7% and 60.4% in gastric carcinoma respectively.The mean value of MVD was 42.5±14.7 in gastric carcinoma.The expressions of HIF-1α,VEGF and the value of MVD were significantly correlated with the depth of invasion,lymph node metastasis and TNM stage.The HIF-1α expression was positively correlated with VEGF expression and MVD value.Conclusion The overexpression of HIF-1α,VEGF and MVD consist in gastric carcinoma tissue.The HIF-1α expression is positively correlated with VEGF expression and MVD value.The overexpression of HIF-1α,VEGF and MVD value are closely related with invasion,metastasis and poor biological behavior of gastric carcinoma.