2009•Acta Academiae Medicinae ZunyiRequires access
Effect of Arsenic on the proliferation of human hepatocyte cells in vitro
Zou Ya
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Abstract
Objective To reseaech the inhibitory effects of arsenic on Human hepatocyte cells proliferation. Methods cultured Human hepatocyte cells,MTT was used to detect the survival rate of L-02 cells With different concentrations of sodium arsenite.Results the survival rate of L -02 cells was apparently higher after 2.5mmol/L NaAsO2 treatment,and 5mmol/L、10mmol/L NaAsO2 reduced the survival rate (P0.01).Conclusions The proliferation of the Human hepatocyte cells line is regulated in a double -phase manner, low concentration (2.5mmol/L) induces stimulation effect,but high concentration(5mmol/L、10mmol/L)inhibits the cell proliferation, hormesis are appeared toxicology.