Expressions of NF-κB and VEGF in Non-Small Cell Lung Cancer and the Relationships between them and Tumor Angiogenesis

Objective: To investigate the expression of vascular endothelial growth factor(VEGF),NF-κB and the relationship with tumor angiogenesis in non-small cell lung cancer(NSCLC).Methods: Expressions of NF-κB P65,VEGF in NSCLC(n=56)and benign tumor tissue(n=20) were detected by immunohistochemical staining.A monoclonal antibody directed against CD34 to identify intratumoral microvessel density(iMVD).Results: The positive expression rates of NF-κB P65,VEGF in NSNLC tissue were 83.9%,69.6% respectively with significantly higher than those of benign tumor tissue(P0.05).The expression level of NF-κB P65 was related with tumor stages,lymphnode involvement,pleural metastasis and smoking of patients(P 0.05).The expression level of VEGF was related to lymphnode involvement and pleural metastasis.There was statistically significant correlation between the expression of NF-κ P65 and VEGF,NF-κB P65 and MVD,VEGF and MVD,respectively(P 0.05).Conclusion: The high expressions of NF-κB P65 and VEGF in NSCLC tissues may be related with tumor invasion and angiogenesis.