Central Venous Catheter Chest Tube Drainage Combined with Urokinase Perfusion for Tuberculous Pleural Effusion

Objective To explore the clinical efficacy of central venous catheter chest tube drainage combined with urokinase perfusion in the treatment of tuberculous pleural effusion.Methods Fifty-six patients with tuberculosis pleural effusion were divided into experiment group(n=32) and control group(n=24) according to different treatment methods.All patients were given antituberculosis drugs and antipyretic and symptomatic treatment.Chest tube placement was performed using central venous catheters in the largest and deepest effusion areas after pleural fluid positioning by color Doppler ultrasound.Then pleural effusion was intermittently emitted or aspirated(800-1 500 mL per time).After effusion emission,the experiment group was treated with a mixed solution of 20 mL normal saline and 250 000 U urokinase and the control group was given a mixed solution of 20 mL normal saline and 2 500 U heparin.Of the 20 mL mixed solution,15 mL solution was injected into the chest through central venous catheter and 5 mL solution was used to seal the tube.Patients were treated for 7-14 days.Results Compared with control group,the total effective rate significantly increased but the incidence of parcel pleural effusion and catheter blockage obviously decreased in experiment group(all P0.05).In addition,the volume of drainage from the chest tube was statistically significant between the two groups(P0.05).Conclusion Central venous catheter chest tube drainage combined with urokinase perfusion is an effective and ideal treatment for tuberculous pleural effusiont,with the advantages of thorough drainage and fewer complications.