2014•Zhongguo xin yao zazhiRequires access

Effect of dencichine on coagulation and the hemostatic mechanism

Zhe Wang

Abstract

Objective: To investigate hemostatic mechanism of the effect of dencichine on coagulation,including the effect on coagulation system,platelet aggregation and fibrinolytic system. Methods: Adult SD rats( n =60) and Kunming mice( n =60) were randomly divided into groups,and treated with etamsylate injection, and dencichine DE I( 40 mg·kg-1),DE II( 20 mg·kg-1),DE III( 10 mg·kg-1) and DE IV( 5 mg·kg-1). Changes in coagulation system,platelet aggregation and fibrinolytic system were determined. Results: Compare to control,dencichine shortened the clotting time in mice( P 0. 01),and changed factors of coagulation system( P 0. 05),platelet aggregation and fibrinolytic system( P 0. 01) in rats. Conclusion: The hemostatic effect of dencichine relates to modulation of coagulation system,platelet aggregation and fibrinolytic system.

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Key concepts: Coagulation, Coagulation system, Platelet aggregation, Platelet, Chemistry, Hemostasis, Fibrinolysis, Bleeding time