2004•Unpublished venueRequires access

Effects of reteplase on fibrinolytic and coagulation systems in rabbits

Dong Liu

Abstract

AIM: To investigate the effects of reteplase (Ret) on fibrinolytic and coagulation systems in rabbits. METHODS: The relative parameters of blood coagulation system and fibrinolytic systems were measured. RESULTS: Ret ( 3.75, 7.50, 15.0 MIU·kg -1) lessened the content of plasminogen (Plg) and promoted the plasma fibrinogen degradation product (FDP) significantly, shortened plasma euglobulin lysis time (ELT), prolonged plasma thrombin time (TT),prothrombin time (PT),and active partial thromboplastin time (APTT). CONCLUSION: Ret can promote fibrinolytic system function and inhibit blood coagulation system function.

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Key concepts: Reteplase, Partial thromboplastin time, Coagulation system, Coagulation, Fibrinogen, Thrombin time, Prothrombin time, Thromboplastin