Protective Effect of Dendrobium Mixture on Renal Function of Experimental Diabetic Rats

Objective To observe the effects of Dendrobium mixture(DM) on renal function and morphological change of diabetic rats.Methods Wistar rats were randomly divided into normal control group,model group,DM low-dose group,DM high-dose group and positive drug control group.Wistar rats were fed with high lipid and high glucose diets and intraperitoneally injected with low-dose STZ to establish diabetic rat model of renal injury.The rats were given DM for 12 weeks by gavage,and changes of blood glucose,BUN,Scr,ratio of kidney weight and body weight(KW/BW) and 24 h urinary albumin of rats were observed.The pathomorphological changes in the kidney tissues were observed by light microscopy and electron microscopy.Results The levels of blood glucose,BUN,Scr,KW/BW and 24 h urinary albumin in treatment group were significantly lower than that of model group(P0.01 or P0.05).Pathological changes in each treatment group had significant improvement compared with model group.Conclusion DM can decrease blood glucose of diabetic rats,improve renal function,reduce renal pathological injure,and has protective effect on kidney of diabetic rats.