Study on the anti-tumor effect of numberIfrom Euphorbia Lathyris L in vitro and in vivo

AIM To study the antimour activity of number Ⅰ from Euphorbia Lathyris L both in vitro and in vivo , and the effect on mice immune organs. METHODS In vitro and in vivo study on the pharmacological activity of numberⅠ from Euphorbia Lathyris L was performed by using MTT method and mice transplant tumor model respectively, in vivo mice neoplasia weight,anti rate,thymus exponent, spleen exponent and leukocyte number were applied to detect the inhibition of S 180 and EAC in mice. RESULTS Number Ⅰfrom Euphorbia Lathyris L had the activity on anti tumor in vitro but no and in vivo influenceon on mice immune organs. CONCLUSION NumberⅠfrom Euphorbia Lathyris L has not only obvious inhibitory tumor activity on human tumor cell strains such as HeLa cells in vitro , but also antitumor efficacy on mice transplant tumor such as S 180 and EAC in vivo . It has no influence on immunological function.