Condensation Reaction of Fmoc-protected Amino Acid and Wang Resin

The influence of Fmoc-protected amino acid,substitution and particle size of Wang resin and stirring modes on the condensation reaction efficiency of Fmoc-protected amino acid and Wang resin were studied.It is found that the molecular size of Fmoc-protected amino acid affected the efficiency of condensation reaction,the small the amino acid is,the higher the efficiency of condensation reaction will be;when the substitution of Wang resin is higher,Fmoc-protected amino acid conjoined before hindering the later condensation reaction,so that the hindered condensation reaction efficiency decrease.