2009•Di-Si Junyi Daxue xuebaoRequires access

Effect of proliferation and apoptosis on LoVo cells by matrine injections in vitro

Yuan Zhou

Abstract

AIM:To investigate the effect of proliferation and apoptosis on LoVo cells by matrine injections in vitro.METHODS:The inhibition of Matrine injections on Lovo cells was detected by trypanblau staining and MTT.Fluorescence microscopy and flow cytometry were applied to study cell apoptosis of LoVo cells.RESULTS:Matrine infections inhibited the proliferation of LoVo cells in a dose-dependent manner.After treated by matrine,cell apoptosis peak was observed by flow cytometry.The apoptosis rate was(7.3±1.5)% in therapeutic group,higher than that in control group(2.1±0.5)%.CONCLUSION:Matrine injection exerts some anticancer effect,possibly by inhibiting the cell proliferation and inducing the apoptosis.

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Key concepts: Matrine, Apoptosis, Flow cytometry, In vitro, Cell growth, MTT assay, Chemistry, Cell