Dection and Clinical Significance of Vascular Endothelial Cell Damages in Patients with Pregnancy Induced Hypertension Syndrome

Objective To explore the changes and clinical significance of plasma von Willebrand factor (vWF),tissue-type plasminogen activator(tPA)and plasminogen activator inhibitor-1(PAI-1)levels in pa- tients with induced pregnancy hypertension.Methods Plasma vWF、tPA and PAI-1 were determined by ELISA and chromogenic assay respectively in 50 non-pregnancy(control group),50 normal pregnancy women (normal pregnancy group)and 85 patients with preganacy induced hypertension(PIH group).Results In normal late pregnancy group and PIH group vWF,tPA and PAI-1 were significently higher than those of con- trol group;In PIH group vWF and PAI-1 were significently higher than those of normal pregnancy group but tPA did not.There was a positive correlation between the plasma vWF and PAI-1 levels in moderate and severe PIH group(r=0.723,P＜0.05;r=0.765,P＜0.05 respectively).Conclusion There was endothelial damages in patients with induced pregnancy hypertension.The levels of plasma vWF and PAI-1 may be two in- dices for the surveillance of PIH.It is important for the diagnosis and therapy of PIH to oberserve the changes of their levels.