Effect of dezocine combined with midazolam on sedation in assisted intraspinal anesthesia

OBJECTIVE To observe the effect of dezocine combined with midazolam on sedation in assisted intraspinal anesthesia.METHODS 60 ASA Ⅰ-Ⅱ patients undergoing elective abdominal operation,were randomized equally into two groups: dezocine combined with midazolam group(groupⅠ),fentanyl combined with midazolam group(groupⅡ).Lumbar puncture was performed at the L2-3 interspace.When the level of anesthesia was stabilized after anesthesia,group I intravenous dezocine 0.1 mg·kg-1,midazolam0.03 mg·kg-1;groupⅡintravenous fentanyl 0.01 mg·kg-1,midazolam0.03 mg·kg-1.The Ramesay was used to assess the degree of sedation.RESULTS There was no statistically difference between the two groups of gender,age,body weight,operation time.The sedative effect at 5,60 min after intravenous between the two groups was statistically significant(P0.05).Blood pressure,pulse,oxygen saturation during operation maintained in a safe range.CONCLUSION Dezocine combined with midazolam produced satisfactory sedation and amnesia and little effect on the respiratory and hemodynamic.It is a feasible method of sedation and analgesia for spinal anesthesia.