ScholarLens Back to search
2009•Journal of Molecular Diagnostics and TherapyRequires access

Study on the clinical application of time-resolved fluorescence immunoassay for the detection of neonatal thyroid-stimulating hormone

Zhixiong Li

Open publisher page 0 citations

Abstract

Objective To evaluate the diagnostic value of quantitative diagnostic kit(TRFIA) for neonatal thyroid-stimulating hormone(TSH) by comparing with the abroad kit.Methods Comparing TRFIA kit made from our lab with the neonatal TSH kit from PerkinElmer Inc.,the concentrations of TSH were measured in 258 blood specimens dried on filter papers.Furthermore,ROC curve was used to determine the cut-off value and all the specimens were analyzed statistically.Results The correlation between two quantitative diagnostic kit was no statistically difference,r=0.961(P0.05).Cut-off value was 9.0 μ U/mL,sensitivity was 100%,specificity was 96.4%,concordance with 258 blood specimens was 97.5%,Kappa value was 0.950.Conclusion The diagnostic value of quantitative diagnostic kit(TRFIA) for neonatal TSH can provide good diagnostic value because of its high sensitivity and specificity.

About this research paper

What this paper is about

Objective To evaluate the diagnostic value of quantitative diagnostic kit(TRFIA) for neonatal thyroid-stimulating hormone(TSH) by comparing with the abroad kit.Methods Comparing TRFIA kit made from our lab with the neonatal TSH kit from PerkinElmer Inc.,the concentrations of TSH were measured in 258 blood specimens dried on filter papers.Furthermore,ROC curve was used to determine the cut-off value and all the specimens were analyzed statistically.Results The correlation between two quantitative diagnostic kit was no statistically difference,r=0.961(P0.05).Cut-off value was 9.0 μ U/mL,sensitivity was 100%,specificity was 96.4%,concordance with 258 blood specimens was 97.5%,Kappa value was 0.950.Conclusion The diagnostic value of quantitative diagnostic kit(TRFIA) for neonatal TSH can provide good diagnostic value because of its high sensitivity and specificity.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To evaluate the diagnostic value of quantitative diagnostic kit(TRFIA) for neonatal thyroid-stimulating hormone(TSH) by comparing with the abroad kit.Methods Comparing TRFIA kit made from our lab with the neonatal TSH kit from PerkinElmer Inc.,the concentrations of TSH were measured in 258 blood specimens dried on filter papers.Furthermore,ROC curve was used to determine the cut-off value and all the specimens were analyzed statistically.Results The correlation between two quantitative diagnostic kit was no statistically difference,r=0.961(P0.05).Cut-off value was 9.0 μ U/mL,sensitivity was 100%,specificity was 96.4%,concordance with 258 blood specimens was 97.5%,Kappa value was 0.950.Conclusion The diagnostic value of quantitative diagnostic kit(TRFIA) for neonatal TSH can provide good diagnostic value because of its high sensitivity and specificity.

Key concepts: Medicine, Thyroid-stimulating hormone, Congenital hypothyroidism, Concordance, Thyroid, Immunoassay, Internal medicine, Hormone

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Study on the clinical application of time-resolved fluorescence immunoassay for the detection of neonatal thyroid-stimulating hormone — Research Paper | ScholarLens