Management of Remifentanil Combined with Propofol for Nasal Endoscopy

Objective To compare the safety and effectiveness of remifentanil combined propofol and fentanyl combined with propofol for nasal endoscopy anesthesia safety and effectiveness. Methods 60 patients undergoing for nasal endoscopy were randomly divided into two groups(n=30),remifentanil combined propofol group(group Ⅰ) and fentanyl combined propofol group(group II). Anesthesia was induced with midazolam 0.05~0.1mg/kg,propofol 2mg/kg,remifentanil 2μg/kg or fentanyl 4~ 6μg/kg,vecuronium 0.1mg/kg,intravenous induction and intubation,and was maintained with a continuous infusion of Propofol 4~6mg/(kg·h),Remifentanil 0.2μg/(kg·min) or Fentanyl 2μg/(kg·h),Vecuronium 0.6~0.8μg/(kg·min). Both groups were to be the end of nasal surgery after the cessation of gauze packing iodoform pumped into anesthetics. Comparison of the two groups of induction of anesthesia and intraoperative of heart rate(HR),systolic blood pressure(SBP) and diastolic blood pressure(DBP),the pulse oxygen saturation(SPO2),recovery from anesthesia and adverse reaction,and so on. Results Two groups induction process of systolic blood pressure(SBP) and diastolic blood pressure(DBP),heart rate(HR) than induced the basic value decreased significantly(P0.05),the process of anesthesia group Ⅰ systolic blood pressure(SBP) and heart rate(HR) compared to group II shrink pressure(SBP) and heart rate(HR)(P0.05),between the two groups pulse oxygen saturation(SPO2) comparative no significant difference(P0.05). Group Ⅰ respiratory recovery time,sober,extubation time was shorter than group II(P0.05). Conclusion Remife-ntanil combined with propofol are effective inhibitors of endotracheal intubation in the process of cardiovascular response during anesthesia maintenance hemodynamics in patients with small rate changes,for the maintenance of blood pressure reduction in the level appropriate bleeding,postoperative recovery,rapid extubation.