ScholarLens Back to search
2003•Journal of Zhenjiang Medical CollegeRequires access

Rearrangements of Immunoglobulin Heavy Chain and T Cell Receptor γ Gene in Acute Lymphocytic Leukemia

Jiang Yun

Open publisher page 0 citations

Abstract

Objective:To explore the occurrence rate of rearrangements of immunoglobulin heavy chain (IgH) and T cell receptor γ (TCRγ) genes in the patients with acute lymphocytic leukemia (ALL). Methods: Polymerase chain reaction (PCR) was used to detect IgH and TCRγ gene rearrangements in the bone marrow samples from 19 ALL patients. Results:IgH gene rearrangements were found in 10 patients,and TCRγ gene rearrangements in 5 patients; 2 cases had both gene rearrangements. Conclusion:In ALL,the occurrence of IgH gene rearrangements was higher than that of TCRγ gene rearrangements, and there was the phenomenon of cross rearrangements.

About this research paper

What this paper is about

Objective:To explore the occurrence rate of rearrangements of immunoglobulin heavy chain (IgH) and T cell receptor γ (TCRγ) genes in the patients with acute lymphocytic leukemia (ALL). Methods: Polymerase chain reaction (PCR) was used to detect IgH and TCRγ gene rearrangements in the bone marrow samples from 19 ALL patients. Results:IgH gene rearrangements were found in 10 patients,and TCRγ gene rearrangements in 5 patients; 2 cases had both gene rearrangements. Conclusion:In ALL,the occurrence of IgH gene rearrangements was higher than that of TCRγ gene rearrangements, and there was the phenomenon of cross rearrangements.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective:To explore the occurrence rate of rearrangements of immunoglobulin heavy chain (IgH) and T cell receptor γ (TCRγ) genes in the patients with acute lymphocytic leukemia (ALL). Methods: Polymerase chain reaction (PCR) was used to detect IgH and TCRγ gene rearrangements in the bone marrow samples from 19 ALL patients. Results:IgH gene rearrangements were found in 10 patients,and TCRγ gene rearrangements in 5 patients; 2 cases had both gene rearrangements. Conclusion:In ALL,the occurrence of IgH gene rearrangements was higher than that of TCRγ gene rearrangements, and there was the phenomenon of cross rearrangements.

Key concepts: T-cell receptor, Gene rearrangement, Immunoglobulin heavy chain, Chronic lymphocytic leukemia, Polymerase chain reaction, Gene, Biology, Molecular biology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Rearrangements of Immunoglobulin Heavy Chain and T Cell Receptor γ Gene in Acute Lymphocytic Leukemia — Research Paper | ScholarLens