2009•Journal of clinical and experimental medicineRequires access
Expression of CK-19 in peripheral blood of patients with papillary thyroid carcinoma and papillary thyroid hyperplasia
Huang Ya
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Abstract
Objective To detect serum cytokeratin(CK-19) in patients with papillary thyroid carcinoma(PTC) and nodular goiter with papillary hyperplasia,in order to suggest a diagnostic indicator for thyroid papillary carcinoma.Methods CK-19 expression was determined in 25 cases of nodular goiter with papillary hyperplasia,25 cases of papillary carcinoma,and 25 healthy subjects with enzyme-linked immunosorbent assay(ELISA).Results CK-19 expression level was high in papillary thyroid carcinoma,middle in nodular goiter with papillary hyperplasia,and low in healthy subjects(F=8.371,P0.05).CK-19 expression level in papillary thyroid carcinoma with lymph node metastasis was higher than that in papillary thyroid carcinoma without lymph node metastasis(t=5.371,P0.05).Conclusion CK-19 expression is increased in patients with papillary thyroid carcinoma.CK-19 plays a guiding role in the diagnosis of papillary thyroid carcinoma with lymph node metastasis.