Pathological study of papillary thyroid carcinoma and papillary thyroid hyperplasia

Objective To study the expression of Galectin-3,CK19 and Ki-67 in the papillary thyroid carcinoma and papillary thyroid hyperplasia and to find the differential diagnostic makers. Methods A total of 200 cases, including 100 with papillary thyroid carcinoma and 100 papillary thyroid hyperplasia by Immunohistochemistry. Results The positive rates for Galectin-3,CK19 and Ki-67 in the papillary thyroid carcinoma were 100 %, 97 % and 93 %, which were significantly higher than those in the papillary thyroid hyperplasia (13 %, 31 %, 1 %) (P 0.05). The positive rate which two or three of the 3 makers in the papillary thyroid carcinoma were 94.3 %, and the positive rate which two or three of the 3 makers in the papillary thyroid hyperplasia were 0 %. Conclusion Galectin-3, CK19 and Ki-67 were useful makers to distinguish the papillary thyroid carcinoma from papillary thyroid hyperplasia, especially combined application.