The clinical investigation of Losartan to improvement of renal function in elderly hypertensive patients

Objective To observe the clinical effect of Losartan on renal hemodynamics and function in elderly hypertensive patients.Methods Forty-three elderly hypertensive patients were treated with Losartan, 50-100 mg/d for twelve to seventeen months. The variation of renal hemodynamics and structure, plasma AngⅡ, blood and urine microglobulin of β 2-MG before and after treatment,applying the colour Doppler Ultrasonography and kits,were determined.Results After treatment the pationts' blood pressure have reduced effectively (P0.001). RI,PI and the Vsmax/Vdmin ratio were markedly decreased in left (P0.01) and right (P0.05)kidney after treatment. Thickness of renal arterial wall was significantly decreased (P0.01), the renal arterial diameter were obviously increased (P0.05), β 2-MG in blood and urine were obviously decreased after administration. The level of plasma AngⅡ has a slightly increased trend(P0.05).Conclusions Losartan was effective in reducing hypertension, it also could decrease the renal arterial vessel resistance and increase the renal blood flow and improve the renal vessel structure, decrease the concentration of β 2-MG in blood and urine,and then improved renal function.