Analysis of antimicrobial resistance of 1 300 strains of aerobic gram- negative bacilli isolated from clinical specimens

Objective To investigate antimicrobial resistance of aerobic gram-negative bacilli isolated from clinical specimens and provide guidance of rational use of antimicrobial agents for clinic. Methods 1 300 strains of aerobic gram-negative bacilli isolated from clinical specimens from July 1,2001 to September 30,2003 were performed antimicrobial susceptibility tests. Results The commonly isolated bacteria were: Escherichia coli (405 strains, 31.15%), Pseudomonas aeruginosa (215 strains, 16.54%), Klebsiella pneumonia (214 strains, 16.46%), Acinetobacter baumannii (161 strains, 12.38%) and Enterobacter (112 strains, 8.62%). Imipenem had the lowest antimicrobial susceptibility rate ( 4.77%), followed by ceftazidime ( 20.62%), amikacin ( 22.77%), cefotetan ( 29.23%) and ticarcillin/clavulanic acid ( 29.15%), the resistant rates to ampicillin, ampicillin/sulbactam, the first generation cephalosporins and SMZco were high. Extended spectrum β-lactamase-producing rate of Escherichia coli and Klebsiella pneumonia was 22.98% and 27.57% respectively. Conclusion The resistance of bacteria to antimicrobial agents is a serious problem. Choice of antimicrobial agents should be based on the antimicrobial susceptibility test so as to reduce the occurrence of antimicrobial resistance.