The Susceptibility of Ureaplasma Urealyticum to Fluoroquinolones

Objective To test the susceptibility of clinical Uu isolates from Hengyang area to fluoroquinolone and provide an experimental data for clinical chemotherapy. Method Broth microdilution method was used for susceptibility testing of 86 isolates of Uu to six fluoroquinolones. Results Among six fluoroquinolones, Sparfloxacin and Gatifloxacin were the most active against Uu, with MIC50 being 0.25 μg/ml and 0.5 μg/ml, respectively, with MIC90 being 4 μg/ml for both. Levofloxacin and Ofloxacin were less active, with MIC50 being 1 μg/ml, 2 μg/ml and MIC90 being 4 μg/ml, 8 μg/ml, respectively. Norfloxacin and Ciprofloxacin had the least activity against Uu. Conclusions New fluoroquinolone such as Sparfloxacin, Levofloxacin and Gatifloxacin show greater activity against Uu than the older agents do; Uu is resistant to older fluoroquinolones in varing degrees.